21-(4-Methylphenylsulfonyl)-4,7,13,16-tetraoxa-1,10,21-triazabicyclo[8.8.5]tricosane-19,23-dione: an N-tosylated macrobicyclic dilactam
نویسندگان
چکیده
The macrobicyclic title compound, C(23)H(35)N(3)O(8)S, contains two tertiary amide bridgehead N atoms and a toluene-sulfonamide N atom in the center of the five-atom bridging strand. The mol-ecule has a central cavity that is defined by the 18-membered ring identified by the N(2)O(4) donor atom set and two 15-membered rings with N(3)O(2) donor atom sets. The toluene-sulfonamide N atom adopts an exo orientation with respect to the central cavity, and the tosyl group is oriented on one side of the aza-bridging strand that connects the bridgehead N atoms.
منابع مشابه
6,7,9,10-Tetrahydro-16,22-ethanooxyethano-5,8,11,19-tetraoxa-16,22-diazadibenzo[h,q]cyclooctadecine-17,21-dione: a benzylannelated macrobicyclic diamide
The macrobicyclic title compound, C(24)H(28)N(2)O(7), has two tertiary diamide bridgehead atoms and is composed of a 12-membered ring (N(2)O(2) donor set) and two 18-membered rings (N(2)O(4) donor sets). The solid-state structure shows that each of the amide groups is not coplanar with the adjacent benzene ring and NMR studies indicate that this conformational relationship persists in solution.
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